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services.AddSingleton();We leveraged this existing dependency injection structure to properly set up the AOT DLL build. By defining a custom IoC container and injecting it with the concrete implementations required for offline play we were able to minimize the amount of refactoring necessary to make everything work. For the previous telemetry client example, we simply inject a no-op implementation in the serverless code.

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除了小分子抑制剂,核酸技术也开始在ACH治疗中得到应用。Ribomic开发的RBM-007,通过限制FGF2和FGFR3激活变体之间的过度相互作用发挥功能。2期临床结果显示,RBM-007的疗效与Vosoritide相近(1.5厘米/年),甚至有一名受试者年增长5厘米,且该试验中包括2周一次的注射频率,是当前在研药物中最长的给药间隔。

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Security officials "hugely underestimated the crowd", says Basanta Basnet, editor of Nepal's daily online news portal Online Khabar. "I spoke to security personnel, and also to members of the political class - they said that 'children' were joining."